Senior Principal Operational Scientist – Aging & Metabolism

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

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About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at are searching for the best talent for a Senior Principal Operational Scientist Aging & Metabolism to be in Cambridge MA or Spring House PA.

Purpose:
The Senior Principal Operational Scientist will provide scientific leadership and handson support for translational research in thrombosis sarcopenia and cardiometabolic diseases while also delivering key operational support. This hybrid role combines scientific responsibilities (in vivo and in vitro work) with operational functions including project management coordination of contracting and administrative and laboratory support. The position requires integrating cardiopulmonary disease mechanisms aging biology and metabolic dysfunction while ensuring smooth execution across a crossfunctional research portfolio.

You will be responsible for:

Scientific and Strategic (50%)

• Lead and provide expertise in in vitro and in vivo studies supporting cardiometabolic and cardiopulmonary research.
• Contribute to target identification validation and preclinical strategy development in areas such as HFpEF Group 2 PH vascular dysfunction thrombosis and agerelated muscle loss and weakness.
• Partner with disease area leaders and project teams to develop mechanistic hypotheses and experimental plans aligned with Cardiopulmonary priorities.
• Uphold strong scientific standards through rigorous data interpretation clear internal communication and contributions to publications and presentations.
  

Project Management Coordination and Administrative (50%)

• Support project management for agingfocused cardiopulmonary programs ensuring clear milestones timelines and decision points.
• Prepare and maintain project documentation including development plans data packages governance materials and decisionsupport documents.
• Organize and support internal and external meetings by preparing agendas documenting outcomes and ensuring timely followup on action items.
  

Qualifications / Requirements:

Education:

• Bachelors degree is required
• Masters degree or PhD is highly preferred
  

Required:

• Minimum of 8-10 years experience working in muscle biology cardiovascular and metabolism in the Pharmaceutical/Biotechnology industry (which can include education)
• Strong scientific background in biology (e.g. aging metabolism cardiopulmonary muscle biology) or in chemistry/biologics.
• Experience contributing scientifically to drug discovery or translational programs in cardiometabolic cardiovascular or musclerelated disease.
• Demonstrated experience working in crossfunctional matrixed research teams.
• Strong written and verbal communication skills and the ability to manage multiple priorities effectively.
• Travel up to 10% of the time (domestic and international) defined by business needs.

The anticipated base pay range for this position in the US is $137000 to $235750.

The Company maintains highly competitive performance-based compensation programs. Under current guidelines this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporations performance over a calendar/performance year. Bonuses are awarded at the Companys discretion on an individual basis.

Subject to the terms of their respective plans employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical dental vision life insurance short and long-term disability business accident insurance and group legal insurance.

Subject to the terms of their respective plans employees are eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).

This position is eligible to participate in the Companys long-term incentive program.

Subject to the terms of their respective policies and date of hire employees are eligible for the following time off benefits:

• Vacation 120 hours per calendar year
• Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado 48 hours per calendar year; for employees who reside in the State of Washington 56 hours per calendar year
• Holiday pay including Floating Holidays 13 days per calendar year
• Work Personal and Family Time - up to 40 hours per calendar year
• Parental Leave 480 hours within one year of the birth/adoption/foster care of a child
• Bereavement Leave 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
• Caregiver Leave 80 hours in a 52-week rolling period 10 days
• Volunteer Leave 32 hours per calendar year
• Military Spouse Time-Off 80 hours per calendar year
  

For additional general information on company benefits please go to: job posting is anticipated to close on February 26 2026. The Company may however extend this time-period in which case the posting will remain available on to accept additional applications.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.

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